Allergen research

Fel d1 Laboratory Testing — Overview

AllerGen Select™ uses standardized laboratory procedures to measure Fel d1, the primary allergen produced by cats.
Each test follows strict scientific protocols to ensure reliable, consistent, and reproducible results.

Accuracy & Precision

Accuracy ensures that Fel d1 levels closely reflect the true allergen concentration.
Precision ensures that repeated tests on the same sample produce consistent results.

All results are validated using control samples and monitored through ongoing quality assurance procedures.

Controlled Testing Process
1. Pre-Analytical (Sample Collection)

Saliva is collected using a standardized method
Each sample is linked to a specific cat
Proper labeling and handling are required
Samples are transported under controlled conditions

2. Analytical (Laboratory Measurement)

Samples are analyzed using calibrated laboratory instruments
Automated systems reduce variability and human error
Reagents and materials are verified and quality-controlled
Testing is performed by trained laboratory personnel

3. Post-Analytical (Results & Reporting)

Fel d1 levels are measured and classified
Results are reviewed and validated
Data is reported in a clear and structured format

Understanding Results
Fel d1 levels vary naturally between cats.
Testing provides a measurable indicator of allergen exposure, allowing for classification into selection categories.

⚠️ Important Disclaimer
Fel d1 testing provides measurable data but does not guarantee the absence of allergic reactions. Individual responses may vary.
All adopters are encouraged to visit and interact with the kitten prior to adoption.

Pet-loving, Highly Skilled Research

Fel d 1 is the most important and major cat allergen as it has been observed in up to 95% of individuals with cat allergy. Sixty to 90% of all IgE reactivity to cat dander is against the Fel d 1. The primary production of Fel d 1 takes place in sebaceous, anal, and salivary glands and its highest concentration can be found in the fur and epidermis of a cat. Fel d 1 becomes airborne very easily and then is carried by small particles, which in turn transfers it to environments that have not had any exposure to a cat.
Fel d 1 is a uteroglobin, but the biological role remains a mystery. The allergenicity of inhaled Fel d 1 increases after it manages to bind the mannose receptors present on dendritic cells. This binding initiates the production of IgE and IgG1 specific to Fel d 1.
Higher levels of IgE specific to Fel d 1 have been seen in cat allergic children with allergic asthma as compared to those only with rhinitis.
Published by: Thermo Fisher Scientific Inc

THERMO FISHER SCIENTIFIC INC

More Informations:

Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy:
https://pubmed.ncbi.nlm.nih.gov/35805985/

Fel d 1 Scientific Information: https://www.thermofisher.com/phadia/wo/en/resources/allergen-encyclopedia/e1/e94.html

Evolution and functional significance of cat allergen, Fel d 1:
https://www.jacionline.org/article/S0091-6749(21)02535-5/fulltext

Cat Pelt/Hair Extract U.S. Potency: Updating the Predicate Fel d 1 RID with a mAb-based ELISA:
https://www.jacionline.org/article/S0091-6749(23)02332-1/fulltext

Fel d 4, a cat lipocalin allergen:
//pubmed.ncbi.nlm.nih.gov/15544598/

Analysis of feline and canine allergen components in patients sensitized to pets: https://pubmed.ncbi.nlm.nih.gov/27956908/

Animal allergens and their presence in the environment: https://pubmed.ncbi.nlm.nih.gov/24624129/

A comparative study of the allergens of cat urine, serum, saliva, and pet:
https://pubmed.ncbi.nlm.nih.gov/4056244/

Mammalian lipocalin allergens--insights into their enigmatic allergenicity:
https://pubmed.ncbi.nlm.nih.gov/22093088/

Fel d 1 levels in domestic living rooms are not related to cat color or hair length:
https://pubmed.ncbi.nlm.nih.gov/11590399/

Genetic diversity of cat allergen, Fel d 1:
https://www.jacionline.org/article/S0091-6749(22)01829-2/fulltext

Fel d 2 Scientific Information:
https://www.thermofisher.com/phadia/wo/en/resources/allergen-encyclopedia/e1/e220.html

Fel d 4 Scientific Information:
https://www.thermofisher.com/phadia/wo/en/resources/allergen-encyclopedia/e1/e228.html

Fel d 7 Scientific Information:
https://www.thermofisher.com/phadia/wo/en/resources/allergen-encyclopedia/e1/e231.html

Cat dander Scientific Information:
https://www.thermofisher.com/phadia/wo/en/resources/allergen-encyclopedia/e1.html

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